S-268019

S-268019 is a pharmacological agent that is classified as a serotonin 5-HT3 receptor antagonist. It is primarily used in the treatment of chemotherapy-induced nausea and vomiting (CINV).

Pharmacology

S-268019 works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. It is a highly selective 5-HT3 receptor antagonist with strong binding affinity for the 5-HT3 receptor.

Clinical Use

The primary use of S-268019 is in the prevention and treatment of nausea and vomiting associated with chemotherapy. It is particularly effective in managing CINV that is resistant to other antiemetic therapies.

Side Effects

Common side effects of S-268019 include constipation, headache, and fatigue. In rare cases, it may cause serious side effects such as serotonin syndrome, a potentially life-threatening condition that requires immediate medical attention.

Dosage

The dosage of S-268019 varies depending on the severity of the patient's symptoms and their overall health status. It is typically administered as an intravenous infusion prior to chemotherapy treatment.

See Also

• 5-HT3 antagonist
• Chemotherapy-induced nausea and vomiting
• Serotonin syndrome

References

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