SB-204070
SB-204070 is a chemical compound that acts as a selective antagonist for the 5-HT4 receptor. It is primarily used in scientific research to study the role of the 5-HT4 receptor in various physiological and pathological processes.
Chemical Properties
SB-204070 has a molecular formula of C17H18ClN3O2S and a molecular weight of 363.86 g/mol. The compound is characterized by its high affinity and selectivity for the 5-HT4 receptor, making it a valuable tool in pharmacological studies.
Pharmacology
As a 5-HT4 receptor antagonist, SB-204070 inhibits the action of serotonin at this specific receptor subtype. The 5-HT4 receptor is involved in various functions, including gastrointestinal motility, cognition, and cardiovascular regulation. By blocking this receptor, SB-204070 helps researchers understand the receptor's role in these processes.
Research Applications
SB-204070 is widely used in preclinical research to investigate the therapeutic potential of 5-HT4 receptor modulation. Some of the key areas of research include:
- Gastrointestinal disorders: Studies have explored the use of SB-204070 in conditions like irritable bowel syndrome and gastroparesis.
- Neurological disorders: Research has examined the role of 5-HT4 receptors in Alzheimer's disease and other cognitive disorders.
- Cardiovascular diseases: The compound has been used to study the impact of 5-HT4 receptor antagonism on heart rate and blood pressure.
Safety and Toxicology
The safety profile of SB-204070 is primarily established through animal studies. It is important to note that the compound is used exclusively in research settings and is not approved for clinical use in humans.
See Also
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External Links
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