SKF-38,393
Chemical compound
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SKF-38,393 is a chemical compound that acts as a selective dopamine receptor agonist. It is primarily used in scientific research to study the function of dopamine receptors, particularly the D1 subtype.
Pharmacology
SKF-38,393 is known for its high affinity and selectivity for the D1 receptor over other dopamine receptor subtypes. This selectivity makes it a valuable tool in neuropharmacological research, allowing scientists to isolate and study the specific effects of D1 receptor activation.
Mechanism of Action
As a dopamine receptor agonist, SKF-38,393 mimics the action of dopamine by binding to and activating the D1 receptor. This activation leads to a cascade of intracellular events, including the activation of adenylate cyclase and the subsequent increase in cyclic AMP (cAMP) levels. These molecular events are crucial for understanding the role of D1 receptors in various physiological and pathological processes.
Research Applications
SKF-38,393 is widely used in neuroscience research to investigate the role of D1 receptors in behavior, cognition, and neuropsychiatric disorders. Studies have utilized SKF-38,393 to explore its effects on motor control, reward pathways, and memory.
Related Compounds
Other compounds related to SKF-38,393 include SKF-81,297 and SKF-82,958, which also act as selective D1 receptor agonists. These compounds are often used in conjunction with SKF-38,393 to compare and contrast their pharmacological profiles and effects.
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References
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