Salubrinal
Salubrinal
Salubrinal (pronunciation: sa-lu-bri-nal) is a selective inhibitor of eIF2alpha dephosphorylation and is often used in scientific research to study Endoplasmic Reticulum (ER) stress.
Etymology
The term 'Salubrinal' is derived from the Latin word 'salubris', meaning health-giving; healthy, and the suffix '-al' which is used in forming names of chemical substances.
Function
Salubrinal works by inhibiting the dephosphorylation of eIF2alpha, a protein that plays a crucial role in the initiation of protein synthesis. By doing so, it helps in reducing ER stress, which is often associated with various diseases such as Alzheimer's disease, Parkinson's disease, and cancer.
Usage
In scientific research, Salubrinal is used as a tool to study the effects of ER stress on cells and to understand the mechanisms of diseases related to ER stress. It is also used to investigate the role of eIF2alpha phosphorylation in protein synthesis and cell survival.
Related Terms
- eIF2alpha: A protein that plays a crucial role in the initiation of protein synthesis.
- Endoplasmic Reticulum (ER): A type of organelle in the cells of eukaryotic organisms that plays a key role in protein synthesis and folding, as well as lipid metabolism.
- ER stress: A condition that occurs when the endoplasmic reticulum becomes overwhelmed with unfolded or misfolded proteins.
- Protein synthesis: The process by which cells generate new proteins.
External links
- Medical encyclopedia article on Salubrinal
- Wikipedia's article - Salubrinal
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