Schilling test

Schilling test is a medical procedure used to determine whether the body absorbs vitamin B12 properly. It was named after American physician Robert F. Schilling, who developed the test.

Overview

The Schilling test is used to determine whether the body absorbs vitamin B12, a nutrient necessary for neurological function and red blood cell production, properly. The test is used to diagnose pernicious anemia, a condition that can lead to a vitamin B12 deficiency.

Procedure

The Schilling test is performed in two parts. In the first part, the patient is given a small dose of radioactive vitamin B12 to swallow. A few hours later, the level of radioactive vitamin B12 in the patient's urine is measured. If the level is low, it suggests that the body is not properly absorbing the vitamin.

In the second part of the test, the patient is given a protein called intrinsic factor along with the radioactive vitamin B12. If the level of radioactive vitamin B12 in the urine increases, it suggests that the body is able to absorb the vitamin when it is combined with intrinsic factor.

Results

The results of the Schilling test can help diagnose various conditions related to vitamin B12 absorption. These include pernicious anemia, atrophic gastritis, and malabsorption syndromes.

Risks

The Schilling test is generally safe, but it does involve exposure to a small amount of radiation. The amount of radiation is similar to that of an X-ray and is not considered harmful.

See also

• Vitamin B12
• Pernicious anemia
• Atrophic gastritis
• Malabsorption syndromes

References

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