Selective androgen receptor modulator
Selective androgen receptor modulators (SARMs) are a class of therapeutic compounds that have similar properties to anabolic agents, but with reduced androgenic properties. This property allows SARMs the advantage of androgen-receptor specificity, tissue selectivity, and the lack of steroid-related side effects.
Mechanism of action
SARMs provide the benefits of traditional anabolic/androgenic steroids such as testosterone (including increased muscle mass, fat loss, and bone density), while offering a lower tendency to produce unwanted side effects. They are a unique class of molecules currently under development for treatment of many diseases, osteoporosis, and muscle wasting.
Medical uses
SARMs have been studied in the treatment of breast cancer and cachexia (muscle wasting syndrome) caused by chronic diseases such as cancer, heart failure, and liver disease. They are also used in the treatment of osteoporosis.
Side effects
While SARMs are not as powerful as regular steroids, they are not without side effects. Some reported side effects include acne, liver damage, breast tissue development, and shrinking of the testicle in males, and deepening of the voice, growth of hair on the face, stomach, upper back, and abnormal menstrual cycles in females. The FDA has not approved any SARMs to treat these medical conditions.
Legal status
In the United States, SARMs are not approved for medical use, but they are legal to buy and sell as "research chemicals". In the European Union, SARMs are classified as novel foods, which means they cannot be sold as supplements.
See also
Selective androgen receptor modulator
Ostarine
AR agonist antagonist SARM
Testosterone Enobosarm overlay
Andarine structure
BMS-564,929
GLPG-0492
Ostarine structure
GSK-971086
GSK-2849466
GSK2881078
GTx-027
LGD-2941
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