Splice site
Splice Site
Splice site (pronunciation: /ˈsplaɪs saɪt/) is a specific location within the pre-mRNA sequence where RNA splicing occurs.
Etymology
The term "splice site" is derived from the English word "splice," which means to join or connect, and "site," referring to a specific location. It was first used in the context of molecular biology in the late 20th century.
Definition
A splice site is a region of gene sequence at the beginning and end of an intron that is recognized by the splicing machinery. The splicing process involves the removal of introns and joining of exons in the pre-mRNA to form a mature mRNA molecule. This process is crucial for proper gene expression and protein synthesis.
Types of Splice Sites
There are two main types of splice sites: the 5' splice site (also known as the donor site) and the 3' splice site (also known as the acceptor site). The 5' splice site is located at the 5' end of the intron, while the 3' splice site is located at the 3' end of the intron.
Related Terms
- Alternative splicing: A process by which different forms of mature mRNA molecules are generated from the same pre-mRNA.
- Spliceosome: A large complex of RNA and protein molecules that carries out RNA splicing.
- Splicing factor: A protein involved in the splicing process.
- Splice variant: A form of mRNA produced by alternative splicing.
External links
- Medical encyclopedia article on Splice site
- Wikipedia's article - Splice site
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