Apicomplexa

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Apicomplexa

Apicomplexa, a phylum of parasitic protists

Apicomplexa is a phylum of parasitic protists that includes a diverse group of organisms. They are characterized by the presence of a unique organelle called the apical complex, which is involved in host cell invasion. Apicomplexa are known for their ability to cause diseases in a wide range of hosts, including humans, animals, and plants.

Taxonomy

Apicomplexa is a phylum within the kingdom Protista. It is further divided into several classes, including Sporozoa, Coccidia, and Piroplasmida. Each class contains multiple orders, families, and genera, representing the vast diversity within this phylum.

Morphology

Apicomplexa are typically unicellular organisms, although some species may form colonies or aggregates. They have a complex life cycle, often involving multiple hosts. The characteristic feature of Apicomplexa is the apical complex, which consists of specialized organelles involved in host cell recognition and invasion. Other notable structures include the apicoplast, a non-photosynthetic plastid, and the rhoptries and micronemes, which are involved in the secretion of proteins during invasion.

Life Cycle

The life cycle of Apicomplexa is often complex and involves both sexual and asexual reproduction. It typically begins with the ingestion of infectious forms, such as oocysts or sporozoites, by a suitable host. Once inside the host, the parasites undergo a series of developmental stages, which may involve replication, differentiation, and migration to different tissues or organs. Eventually, the parasites produce specialized forms, such as gametocytes, which can be taken up by another host to continue the life cycle.

Pathogenicity

Many Apicomplexa are pathogenic and can cause significant diseases in their hosts. Examples include Plasmodium, the causative agent of malaria, and Toxoplasma gondii, which causes toxoplasmosis. These parasites have evolved sophisticated mechanisms to invade host cells, evade the immune system, and establish chronic infections. The diseases caused by Apicomplexa can have serious consequences for human and animal health, as well as economic impacts on agriculture and livestock production.

Importance

Despite their pathogenic nature, Apicomplexa also play important ecological roles. They are key players in various ecosystems, where they can regulate populations of their hosts or serve as prey for other organisms. Additionally, some Apicomplexa have been studied extensively as model organisms, providing valuable insights into fundamental biological processes such as cell invasion, organelle biogenesis, and host-parasite interactions.

References


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Contributors: Prab R. Tumpati, MD