Sublingual administration
Sublingual Administration
Sublingual administration (/sʌbˈlɪŋɡwəl/; from Latin sub- "under" + lingua "tongue") is a method of drug administration where the drug is placed under the tongue to be absorbed by the body.
Etymology
The term "sublingual" is derived from the Latin words sub meaning "under" and lingua meaning "tongue". This term accurately describes the method of administration, as the drug is placed under the tongue for absorption.
Method
In sublingual administration, the substance is placed under the tongue where it dissolves and is absorbed into the bloodstream through the mucous membranes of the oral cavity. This method bypasses the first pass metabolism in the liver, allowing for a faster onset of action and higher bioavailability of the drug.
Advantages and Disadvantages
Sublingual administration has several advantages over other methods of drug administration. It allows for a rapid onset of action, as the drug is quickly absorbed into the bloodstream. It also avoids the first pass metabolism in the liver, which can degrade some drugs and reduce their effectiveness. However, not all drugs can be administered sublingually, and some may cause irritation or discomfort in the oral cavity.
Related Terms
- Buccal administration: A method of drug administration where the drug is placed between the gum and the cheek.
- Oral administration: A method of drug administration where the drug is swallowed and absorbed in the gastrointestinal tract.
- First pass effect: The metabolism of a drug in the liver before it reaches systemic circulation.
- Mucous membrane: The moist tissue that lines certain parts of the inside of your body, including your nose, mouth, throat, and reproductive organs.
External links
- Medical encyclopedia article on Sublingual administration
- Wikipedia's article - Sublingual administration
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