Tetrahydrofuran

Tetrahydrofuran (THF) is an organic compound with the formula (CH2)4O. This colorless, volatile, mobile liquid, which is slightly water-soluble, is primarily used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent.

Properties

Tetrahydrofuran is a colorless liquid with an ether-like odor. It is highly flammable and can form explosive peroxides upon storage in the presence of air. The substance is stable under recommended storage conditions.

Production

Commercially, tetrahydrofuran is produced on a large scale from 1,4-butanediol. The method involves dehydration of 1,4-butanediol at high temperatures over an acidic catalyst.

Uses

Tetrahydrofuran is a widely used industrial solvent. It is a direct precursor to polymers. Poly(tetramethylene ether) glycol (PTMEG), a polymer used for high-performance athletic apparel and swimsuits, is derived from THF.

Safety

Exposure to tetrahydrofuran can cause irritation to the eyes and respiratory tract. Prolonged skin contact may cause dermatitis, a skin condition characterized by red, itchy skin.

See also

• Ether (chemistry)
• 1,4-Butanediol
• Polymer

References

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  Crystal structure of Tetrahydrofuran

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  Tetrahydrofuran peroxide formation

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  Annonacin

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  Eribulin