Tofisopam

Tofisopam is a benzodiazepine derivative with unique properties. Unlike most benzodiazepines, it does not have anticonvulsant, sedative, skeletal muscle relaxant, motor skill-impairing or amnestic properties. It is primarily anxiolytic and acts as a serotonin antagonist and dopamine agonist.

Pharmacology

Tofisopam is a 2,3-benzodiazepine, which has a unique profile of pharmacological activity compared to the 1,4-benzodiazepines. It is a selective anxiolytic, without sedative, muscle relaxant, or anticonvulsant effects. Tofisopam also has anti-aggressive properties and enhances serotonin turnover in the brain.

Medical uses

Tofisopam is used for the treatment of anxiety disorders and for short-term relief of the symptoms of anxiety. It is also used to treat irritable bowel syndrome and to help manage alcohol withdrawal syndrome.

Side effects

The most common side effects of Tofisopam are dizziness, headache, and gastrointestinal disturbances. Rare side effects include skin rash, changes in libido, and mood changes.

History

Tofisopam was first synthesized in the 1960s by the Hungarian pharmaceutical company Egis Pharmaceuticals. It is marketed in several countries worldwide, including Hungary, Japan, India, and some countries in Europe.

See also

• Benzodiazepine
• Anxiety disorder
• Irritable bowel syndrome
• Alcohol withdrawal syndrome

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  Tofisopam structure

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  Tofisopam ball-and-stick model