Toxicogenomics
Toxicogenomics (pronounced: tox-ee-co-ge-no-mics) is a scientific discipline that combines the study of toxicology and genomics to understand the response of an organism's genome to harmful substances.
Etymology
The term "Toxicogenomics" is derived from the words "toxicology" and "genomics". "Toxicology" (from the Greek τοξικός, toxikos, "poisonous", and -λογία, -logia) is the study of the adverse effects of chemical substances on living organisms, while "genomics" is the study of the full genetic complement of an organism (the genome).
Overview
Toxicogenomics involves the application of genomic technologies, such as DNA sequencing, bioinformatics, and DNA microarray analysis, to study the effects of toxins on gene expression. This field aims to understand the relationship between the exposure to certain toxins and the resulting changes in gene expression, which can lead to various diseases.
Related Terms
- Genotoxicity: The property of chemical agents that damages the genetic information within a cell causing mutations, which may lead to cancer.
- Pharmacogenomics: The study of how genes affect a person's response to drugs. This relatively new field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective, safe medications and doses that will be tailored to a person's genetic makeup.
- Epigenomics: The study of the complete set of epigenetic modifications on the genetic material of a cell, known as the epigenome.
- Proteomics: The large-scale study of proteins, particularly their structures and functions.
See Also
External links
- Medical encyclopedia article on Toxicogenomics
- Wikipedia's article - Toxicogenomics
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