Vantictumab

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Vantictumab (pronounced van-tic-tu-mab) is a monoclonal antibody designed for the treatment of cancer. It is an experimental drug that targets the Wnt signaling pathway, which is often implicated in the growth and spread of cancer cells.

Pronunciation

The pronunciation of Vantictumab is "van-tic-tu-mab".

Etymology

The name "Vantictumab" is derived from the Latin "vantic", meaning "prophetic", and "mab", a common suffix for monoclonal antibodies. The "prophetic" part of the name refers to the drug's potential to predict and target cancer cells.

Mechanism of Action

Vantictumab works by binding to a protein called Frizzled, which is part of the Wnt signaling pathway. This binding prevents Wnt proteins from interacting with Frizzled, thereby inhibiting the signaling pathway and potentially slowing or stopping the growth of cancer cells.

Clinical Trials

Vantictumab has been tested in several clinical trials for various types of cancer, including breast cancer, pancreatic cancer, and non-small cell lung cancer. The results of these trials have been mixed, with some showing promise and others showing little to no effect.

Related Terms

  • Monoclonal antibody: A type of protein made in the lab that can bind to substances in the body, including cancer cells.
  • Wnt signaling pathway: A complex network of proteins best known for their roles in embryogenesis and cancer, but also involved in normal physiological processes in adult animals.
  • Frizzled: A family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway.
  • Clinical trial: A research study that tests how well new medical approaches work in people.

External links

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