Vesamicol

A drug that inhibits acetylcholine storage in synaptic vesicles

Vesamicol is a pharmacological agent that acts as an inhibitor of the vesicular acetylcholine transporter (VAChT). This compound is primarily used in research settings to study the cholinergic system and its role in various physiological and pathological processes.

Mechanism of Action

Vesamicol functions by inhibiting the VAChT, which is responsible for transporting acetylcholine into synaptic vesicles within cholinergic neurons. By blocking this transporter, vesamicol effectively reduces the storage of acetylcholine in vesicles, leading to decreased release of this neurotransmitter into the synaptic cleft. This action results in diminished cholinergic transmission, which can be useful for studying the effects of reduced acetylcholine activity in the nervous system.

Pharmacological Effects

The inhibition of acetylcholine storage by vesamicol can lead to a variety of effects depending on the system being studied. In the central nervous system, reduced cholinergic activity can affect processes such as learning, memory, and motor control. In the peripheral nervous system, vesamicol can influence autonomic functions and neuromuscular transmission.

Research Applications

Vesamicol is primarily used in experimental research to investigate the role of acetylcholine in various biological systems. It is particularly valuable in studies of neurodegenerative diseases such as Alzheimer's disease, where cholinergic dysfunction is a hallmark. By modulating acetylcholine levels, researchers can better understand the contributions of cholinergic pathways to disease progression and symptomatology.

Chemical Properties

Vesamicol is a piperidine derivative with the chemical formula C₁₇H₂₅NO. It is characterized by a cyclohexanol group linked to a phenylpiperidine moiety. The compound is typically synthesized in laboratory settings for research purposes.

Safety and Handling

As with many research chemicals, vesamicol should be handled with care in a controlled laboratory environment. Appropriate safety measures, including the use of personal protective equipment, should be employed to prevent exposure.

Related Pages

• Acetylcholine
• Cholinergic system
• Neurotransmitter
• Synaptic vesicle
• Alzheimer's disease