Volume of distribution
Volume of Distribution
Volume of Distribution (pronounced: /ˈvɒl.juːm ɒv ˌdɪs.trɪˈbjuː.ʃən/) is a pharmacokinetic concept used to describe the distribution of drugs in the body as relative to the administered dose.
Etymology
The term "Volume of Distribution" is derived from the field of Pharmacokinetics, where "volume" refers to the apparent space in the body available to contain the drug, and "distribution" refers to the dispersion or dissemination of substances throughout the fluids and tissues of the body.
Definition
The Volume of Distribution (Vd) is defined as the theoretical volume in which the total amount of drug would need to be uniformly distributed to produce the observed blood concentration. It is a hypothetical volume and does not necessarily reflect any physiological or anatomical volume.
Calculation
The Volume of Distribution is calculated using the formula:
Vd = (Amount of drug in the body) / (Plasma drug concentration)
Related Terms
- Pharmacokinetics: The study of how an organism affects a drug, including absorption, distribution, metabolism, and excretion.
- Plasma Drug Concentration: The amount of a drug present in the blood at a particular time after the drug has been administered.
- Drug Metabolism: The process by which the body breaks down and converts medication into active chemical substances.
- Drug Excretion: The process by which the body removes waste products of drug metabolism.
External links
- Medical encyclopedia article on Volume of distribution
- Wikipedia's article - Volume of distribution
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