WB-4101

WB-4101

WB-4101 is a chemical compound known for its role as a selective antagonist of the α1B-adrenergic receptor. This receptor is one of the subtypes of alpha-1 adrenergic receptors, which are part of the adrenergic receptor family. These receptors are involved in various physiological processes, including the regulation of vascular smooth muscle contraction and neurotransmitter release.

Chemical Properties

WB-4101 is classified as a quinazoline derivative. Quinazolines are a class of organic compounds with a bicyclic structure composed of two fused six-membered rings, a benzene ring, and a pyrimidine ring. The specific chemical structure of WB-4101 allows it to bind selectively to the α1B-adrenergic receptor, inhibiting its activity.

Pharmacology

As an α1B-adrenergic receptor antagonist, WB-4101 is used primarily in pharmacological research to study the function of this receptor subtype. The α1B-adrenergic receptor is implicated in the regulation of blood pressure and vascular tone. By blocking this receptor, WB-4101 can help elucidate the physiological and pathological roles of α1B-adrenergic receptors in various tissues.

Applications in Research

WB-4101 has been utilized in numerous scientific studies to investigate the role of α1B-adrenergic receptors in different biological systems. For example, it has been used to study the effects of α1B-adrenergic receptor antagonism on cardiovascular function, central nervous system activity, and smooth muscle contraction.

Related Compounds

Other compounds related to WB-4101 include prazosin, terazosin, and doxazosin, which are also α1-adrenergic receptor antagonists but with varying selectivity for different receptor subtypes. These compounds are often used in the treatment of hypertension and benign prostatic hyperplasia.

See Also

• Adrenergic receptor
• Alpha-1 adrenergic receptor
• Quinazoline
• Pharmacology
• Hypertension
• Benign prostatic hyperplasia

References

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