Zosuquidar trihydrochloride
Zosuquidar trihydrochloride
Zosuquidar trihydrochloride (pronunciation: zo-soo-kwi-dar tri-hydro-chloride) is a potent and selective P-glycoprotein inhibitor. It is a synthetic, third-generation anthranilic acid derivative with potential chemosensitizing activity.
Etymology
The term "Zosuquidar" is a coined name for this specific chemical compound. The "trihydrochloride" part of the name refers to the presence of three hydrochloride groups in the compound's chemical structure.
Function
Zosuquidar trihydrochloride inhibits the activity of the ATP-binding cassette transporter P-glycoprotein, which is often overexpressed in cancer cells and is involved in the efflux of drugs out of the cells, leading to multi-drug resistance. By inhibiting P-glycoprotein, zosuquidar trihydrochloride may increase the intracellular concentrations of certain anti-cancer drugs and enhance their cytotoxic effects.
Related Terms
- P-glycoprotein: A protein that pumps many foreign substances out of cells.
- ATP-binding cassette: A family of transporter proteins that use energy from ATP hydrolysis to carry out certain biological processes, including translocation of various substrates across membranes.
- Anthranilic acid: An aromatic acid, the ortho-isomer of benzoic acid, that is used in the manufacture of dyes, pharmaceuticals, and perfumery.
- Chemosensitizing: The process of making cancer cells more sensitive to chemotherapy.
See Also
External links
- Medical encyclopedia article on Zosuquidar trihydrochloride
- Wikipedia's article - Zosuquidar trihydrochloride
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