5-HT3 antagonist
5-HT3 Antagonist
5-HT3 antagonist (pronunciation: five-HT-three antagonist) is a type of medication that acts on the 5-HT3 receptor, a subtype of the Serotonin receptor.
Etymology
The term "5-HT3 antagonist" is derived from the receptor it acts upon, the 5-HT3 receptor. "5-HT" is an abbreviation for 5-hydroxytryptamine, the chemical name for serotonin. "Antagonist" refers to the drug's action of blocking or inhibiting the receptor.
Function
5-HT3 antagonists are primarily used to prevent nausea and vomiting caused by chemotherapy drugs. They work by blocking the action of serotonin, a substance that triggers nausea and vomiting, at the 5-HT3 receptors in the brain and in the small intestine.
Examples
Examples of 5-HT3 antagonists include Ondansetron, Granisetron, and Dolasetron. These drugs are often used in combination with other antiemetic medications to increase their effectiveness.
Related Terms
- Serotonin: A neurotransmitter that is involved in the transmission of nerve impulses. Serotonin can trigger nausea and vomiting when it binds to 5-HT3 receptors.
- Chemotherapy: A type of cancer treatment that uses drugs to destroy cancer cells.
- Anti-emetic: A drug that is effective against vomiting and nausea.
- Neurotransmitter: Chemicals that transmit signals from a neuron to a target cell across a synapse.
External links
- Medical encyclopedia article on 5-HT3 antagonist
- Wikipedia's article - 5-HT3 antagonist
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