Acquired perforating dermatosis

Acquired Perforating Dermatosis

Acquired perforating dermatosis (pronunciation: a-kwīrd pər-fôr-āt-ing dər-mə-tō-səs) is a rare skin disorder characterized by papules and nodules that penetrate the dermis. The etymology of the term is derived from the Latin acquirere meaning "to obtain", the Latin perforare meaning "to pierce through", and the Greek dermatosis meaning "skin condition".

Definition

Acquired perforating dermatosis is a skin condition that typically occurs in patients with chronic systemic diseases, particularly renal disease and diabetes mellitus. It is characterized by hyperkeratotic papules and nodules that perforate the skin, leading to the extrusion of dermal contents.

Symptoms

The primary symptoms of acquired perforating dermatosis include pruritic, hyperkeratotic papules and nodules that may be umbilicated. These lesions often occur on the extremities, particularly the dorsa of the hands, arms, and legs. The lesions may also be accompanied by intense itching.

Causes

While the exact cause of acquired perforating dermatosis is unknown, it is often associated with systemic diseases such as chronic kidney disease and diabetes mellitus. Other associated conditions include hypothyroidism, liver disease, and malignancies.

Treatment

Treatment for acquired perforating dermatosis often involves managing the underlying systemic disease. Topical treatments such as retinoids, corticosteroids, and calcipotriol may also be used. In severe cases, systemic treatments such as methotrexate, cyclosporine, and acitretin may be considered.

See Also

• Dermatology
• Skin Lesion
• Chronic Kidney Disease
• Diabetes Mellitus

External links

• Medical encyclopedia article on Acquired perforating dermatosis
• Wikipedia's article - Acquired perforating dermatosis

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