Azelastine hydrochloride
Azelastine hydrochloride
Azelastine hydrochloride (pronunciation: a-ZEL-as-teen HYE-droe-KLOR-ide) is a potent, second-generation, selective, histamine antagonist (H1-receptor) used as a nasal spray to treat allergic and non-allergic rhinitis.
Etymology
The term 'Azelastine' is derived from the parent compound phthalazinone, and the suffix '-astine' is a common ending for antihistamines. The 'hydrochloride' part of the name refers to the hydrochloride salt form of the drug, which enhances its solubility for medicinal use.
Pharmacology
Azelastine hydrochloride is a phthalazinone derivative that exhibits a marked antihistamine effect and also possesses potent anti-allergic properties. It inhibits the release of histamine from mast cells, thereby preventing the symptoms of allergic reactions.
Indications
Azelastine hydrochloride is indicated for the treatment of the symptoms of allergic rhinitis such as sneezing, itchy or runny nose, and itchy or watery eyes. It is also used to treat symptoms of non-allergic rhinitis.
Side Effects
Common side effects of Azelastine hydrochloride include bitter taste, headache, drowsiness, and nasal irritation. Severe side effects are rare but may include allergic reactions like rash, itching, swelling, severe dizziness, and trouble breathing.
Related Terms
External links
- Medical encyclopedia article on Azelastine hydrochloride
- Wikipedia's article - Azelastine hydrochloride
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