CXCR4 antagonist
CXCR4 antagonist
CXCR4 antagonist (pronunciation: /ˈsiːˈɛksˈsiːˈɑːrˈfɔːr ˈæntəˌɡɒnɪst/) is a type of drug that inhibits the action of the CXCR4 receptor, a protein that plays a crucial role in the immune system and in the process of cell migration.
Etymology
The term "CXCR4 antagonist" is derived from the name of the receptor it inhibits, CXCR4, and the term "antagonist", which in pharmacology refers to a substance that interferes with or inhibits the physiological action of another.
Function
CXCR4 antagonists work by binding to the CXCR4 receptor, thereby preventing its natural ligand, CXCL12, from binding. This inhibition can have various effects, including the prevention of HIV entry into cells, the mobilization of hematopoietic stem cells, and the inhibition of cancer cell migration and metastasis.
Related Terms
- CXCR4: The receptor that CXCR4 antagonists inhibit.
- CXCL12: The natural ligand of the CXCR4 receptor.
- Hematopoietic stem cells: The type of stem cells that can be mobilized by CXCR4 antagonists.
- HIV: A virus that can be prevented from entering cells by CXCR4 antagonists.
- Cancer: A disease that can be affected by the action of CXCR4 antagonists.
See Also
External links
- Medical encyclopedia article on CXCR4 antagonist
- Wikipedia's article - CXCR4 antagonist
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