CYP2C9
CYP2C9
CYP2C9 (pronunciation: sɪp tuː siː naɪn) is a gene that encodes a member of the cytochrome P450 superfamily of enzymes. These enzymes are a group of heme-thiolate monooxygenases that metabolize a variety of endogenous and exogenous substances, including fatty acids, steroid hormones, and xenobiotics.
Etymology
The term CYP2C9 is derived from the classification system for cytochrome P450 enzymes, where "CYP" stands for "cytochrome P450", "2C" refers to the family and subfamily, and "9" is the individual gene number.
Function
The CYP2C9 enzyme is primarily found in the liver and is involved in the metabolism of approximately 15% of clinically used drugs, including warfarin, phenytoin, and ibuprofen. Variations in the CYP2C9 gene can lead to altered drug metabolism, which may result in adverse drug reactions or therapeutic failure.
Related Terms
- Cytochrome P450: A large family of enzymes that play a significant role in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
- Warfarin: An anticoagulant drug that is metabolized by the CYP2C9 enzyme.
- Phenytoin: An antiepileptic drug that is metabolized by the CYP2C9 enzyme.
- Ibuprofen: A nonsteroidal anti-inflammatory drug (NSAID) that is metabolized by the CYP2C9 enzyme.
See Also
External links
- Medical encyclopedia article on CYP2C9
- Wikipedia's article - CYP2C9
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