Ceftazidime/avibactam
Ceftazidime/avibactam
Ceftazidime/avibactam (pronunciation: sef-taz-i-deem/avi-bak-tam) is a combination antibiotic used to treat a variety of bacterial infections.
Etymology
The name "Ceftazidime" is derived from the cephalosporin class of antibiotics, of which it is a part. "Avibactam" is a non-β-lactam β-lactamase inhibitor, which is combined with ceftazidime to increase its effectiveness against resistant bacteria.
Usage
Ceftazidime/avibactam is used to treat complicated intra-abdominal infections (cIAI), complicated urinary tract infections (cUTI), including kidney infections (pyelonephritis), hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP), and infections caused by susceptible Gram-negative microorganisms in patients who have limited or no alternative treatment options.
Mechanism of Action
Ceftazidime, a cephalosporin, works by inhibiting the synthesis of the bacterial cell wall, leading to cell death. Avibactam, on the other hand, inhibits certain enzymes (β-lactamases) that often contribute to antibiotic resistance, thereby enhancing the effectiveness of ceftazidime.
Related Terms
External links
- Medical encyclopedia article on Ceftazidime/avibactam
- Wikipedia's article - Ceftazidime/avibactam
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