W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
29,100 pages, 4,107,836 edits & 35,925,855 views.

Free unbiased diet, health and wellness info!

Clozapine

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

Information about Clozapine

Clozapine was the first atypical antipsychotic approved for treatment of schizophrenia.

Clozapine
Clozapine

Liver safety of Clozapine

Because it is associated with severe and potentially fatal side effects (agranulocytosis), its use is restricted to refractory schizophrenia, and monitoring during therapy is required. Clozapine therapy is associated with serum aminotransferase elevations and in rare instances has been linked to clinically apparent acute liver injury.

Mechanism of action of Clozapine

Clozapine (kloe" za peen) is an atypical antipsychotic medication that appears to act both as a dopamine (D) and serotonin (5-HT2) receptor antagonist.

FDA approval information for Clozapine

Clozapine was introduced into clinical practice in 1971, but subsequently withdrawn in 1975 after reports of fatal agranulocytosis with its use. Nevertheless, because of its potent activity, clozapine was approved for restricted use in refractory schizophrenia in the United States in 1989 and only with surveillance using close monitoring of complete blood counts. As a result, use of clozapine has been limited.

Dosage and administration for Clozapine

Clozapine is available as tablets of 25 and 100 mg in generic forms and under the brand names of Clozaril. The dosage of clozapine varies greatly, from 25 to as much as 900 mg daily based upon clinical response and tolerability.

Side effects of Clozapine

Common side effects include sedation, tremors, drooling, dizziness, headache, hypotension and syncope, dry mouth, constipation, and weight gain. Uncommon, but potential severe side effects include severe neutropenia, agranulocytosis, orthostatic hypotension and syncope, falls, seizures, cardiomyopathy, prolongation of the QTc interval, diabetes, dyslipidemia, weight gain and neuroleptic malignant syndrome.

Antipsychotic agents

First Generation

Second Generation (Atypicals)

Cost and Coupons - Clozapine

Reviews for Clozapine

Learn more about Clozapine

Latest research (Pubmed)

PubMed
Wikipedia

External links


edit 

WikiMD needs you!

== Summary ==

This WikiMD article Clozapine is a stub.
If you are a healthcare professional familiar with the topic Clozapine, or
A subject matter expert or authority on Clozapine, you can help us.
About | Mission | Paid editors welcome!

Clozapine is part of WikiMD's ^articles available 4free, 4all & 4ever!
^The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional advice
WIKIMD MAKES NO GUARANTEE OF VALIDITY OF CONTENT. USE THE CONTENT AT YOUR OWN RISK!

A very small portion of the content such as templates etc., when imported from wikipedia, are licensed under CC BY-SA 3.0. ^See full disclaimers and terms of use

W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP*
Special: W8MD's tele-weight loss consultations only $99.99. Call 718-946-5500. Limited acceptance.