Cyclic citrullinated peptide

Cyclic Citrullinated Peptide (CCP)

Cyclic citrullinated peptide (CCP) is a protein that can be detected in the blood of patients with certain diseases. The presence of CCP is often associated with rheumatoid arthritis, a chronic inflammatory disease that affects the joints.

Pronunciation: /ˈsaɪklɪk ˌsɪtrʊˈleɪtɪd ˈpeptʌɪd/

Etymology: The term "cyclic" comes from the Greek word "kuklos", meaning circle. "Citrullinated" refers to the conversion of the amino acid arginine in a protein into the amino acid citrulline - a process called citrullination. "Peptide" is a term used in biochemistry to refer to a type of molecule consisting of two or more amino acids.

Detection and Significance

The presence of CCP in the blood can be detected using a blood test known as the anti-CCP test. This test is often used to help diagnose rheumatoid arthritis and can also provide information about the severity of the disease.

Related Terms

Rheumatoid Arthritis: A chronic inflammatory disorder affecting many joints, including those in the hands and feet.
Citrullination: The conversion of the amino acid arginine in a protein to the amino acid citrulline.
Amino Acid: Organic compounds that combine to form proteins.
Protein: Large, complex molecules that play many critical roles in the body.
Inflammation: A localized physical condition in which part of the body becomes reddened, swollen, hot, and often painful, especially as a reaction to injury or infection.