Filipin
Filipin
Filipin (/fɪlɪpɪn/) is a polyene macrolide that has been isolated from Streptomyces filipinensis. It is a potent antifungal agent and has been used as a biochemical tool in science due to its ability to form complexes with sterols.
Etymology
The term "Filipin" is derived from Streptomyces filipinensis, the bacteria from which it was first isolated. The bacteria itself was named after the Philippines, where it was first discovered.
Usage
Filipin is used in the field of biochemistry as a diagnostic tool. It is particularly useful in the study of Niemann-Pick disease, a type of lysosomal storage disease, as it can bind to unesterified cholesterol in cells, allowing for the identification of cholesterol accumulation.
Related Terms
- Polyene: A type of molecule that contains alternating single and multiple carbon-carbon bonds.
- Macrolide: A class of antibiotics that are characterized by a macrocyclic lactone ring.
- Streptomyces: A genus of Gram-positive bacteria that is notable for its production of antibiotics.
- Niemann-Pick disease: A type of lysosomal storage disease that is characterized by the accumulation of cholesterol in cells.
External links
- Medical encyclopedia article on Filipin
- Wikipedia's article - Filipin
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