Florfenicol
Florfenicol (pronounced: flor-fen-i-col) is a synthetic, broad-spectrum antibiotic that is primarily used in veterinary medicine. It is a derivative of thiamphenicol, and was first introduced in the 1980s in Japan.
Etymology
The term "Florfenicol" is derived from the chemical structure of the compound, which includes a fluorine atom (Flor-) and a phenicol group (-fenicol).
Usage
Florfenicol is used to treat a variety of bacterial infections in animals, including respiratory diseases in cattle and swine, and salmonids bacterial cold-water disease. It is particularly effective against Gram-negative bacteria, but also has activity against some Gram-positive bacteria.
Mechanism of Action
Florfenicol works by inhibiting protein synthesis in bacteria, thereby preventing them from growing and reproducing. It binds to the 50S subunit of the bacterial ribosome, which prevents the addition of new amino acids to the growing peptide chain.
Side Effects
Possible side effects of florfenicol use in animals can include diarrhea, decreased food consumption, and injection site swelling. In rare cases, it can cause severe anemia.
Related Terms
- Chloramphenicol: An older antibiotic that florfenicol is structurally related to.
- Thiamphenicol: The direct precursor to florfenicol, from which it is derived.
- Veterinary Antibiotics: The broader category of drugs that florfenicol falls under.
External links
- Medical encyclopedia article on Florfenicol
- Wikipedia's article - Florfenicol
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