Fluorodeoxyglucose (18F)
Fluorodeoxyglucose (18F)
Fluorodeoxyglucose (18F) (pronounced: floor-oh-dee-ox-ee-gloo-kose), often abbreviated as FDG, is a radiopharmaceutical used in the medical imaging modality Positron Emission Tomography (PET). It is an analogue of glucose, but with the hydroxyl group replaced by 18F-fluorine.
Etymology
The term "Fluorodeoxyglucose" is derived from its chemical structure. "Fluoro" refers to the presence of fluorine, "deoxy" indicates the absence of a hydroxyl group (OH), and "glucose" is the sugar molecule to which the fluorine is attached. The "(18F)" denotes the specific isotope of fluorine used.
Usage
FDG is used as a tracer in PET scan to assess areas of high glucose metabolism, as these areas absorb more of the tracer. This is particularly useful in oncology, as cancer cells often have increased glucose metabolism compared to normal cells.
Synthesis
FDG is synthesized by substituting the hydroxyl group at the 2' position in glucose for 18F-fluorine. This is typically done using a cyclotron.
Related Terms
See Also
External links
- Medical encyclopedia article on Fluorodeoxyglucose (18F)
- Wikipedia's article - Fluorodeoxyglucose (18F)
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