Glymphatic system
Glymphatic System
The Glymphatic System (pronunciation: /ɡlɪmˈfætɪk/ system) is a functional waste clearance pathway for the Central Nervous System (CNS) that was discovered in the early 21st century. The term "glymphatic" is a portmanteau derived from "glial" and "lymphatic".
Etymology
The term "glymphatic" was coined by the Danish researchers Maiken Nedergaard and Helene Benveniste to describe the glial cells' role in the system that functions similarly to the lymphatic system in the rest of the body.
Function
The glymphatic system promotes the elimination of soluble proteins and metabolites from the CNS, and facilitates brain lipid transportation. It also contributes to the distribution of several compounds, such as glucose, lipids, amino acids, growth factors, and neuromodulators.
Structure
The glymphatic system is composed of a network of vessels that run alongside blood vessels, which are lined with astrocytic end-feet expressing aquaporin-4 water channels.
Clinical Significance
The glymphatic system has been found to play a key role in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. It is also involved in brain aging, brain trauma, and stroke.
See Also
References
External links
- Medical encyclopedia article on Glymphatic system
- Wikipedia's article - Glymphatic system
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