Intussusceptive angiogenesis
Intussusceptive Angiogenesis
Intussusceptive angiogenesis (pronunciation: in-tuh-suh-sep-tiv an-gee-oh-gen-uh-sis) is a process involved in the formation of new blood vessels. This process is distinct from the more commonly known sprouting angiogenesis, and is characterized by the splitting of existing blood vessels to form new ones.
Etymology
The term 'intussusceptive' is derived from the Latin words 'intus', meaning 'within', and 'suscipere', meaning 'to take up'. 'Angiogenesis' is derived from the Greek words 'angeion', meaning 'vessel', and 'genesis', meaning 'creation'. Thus, 'intussusceptive angiogenesis' can be interpreted as 'the creation of vessels within'.
Process
Intussusceptive angiogenesis begins with the formation of transluminal tissue pillars in the existing blood vessels. These pillars then expand and split the vessel into two. This process is faster and more efficient than sprouting angiogenesis, as it does not require the migration of endothelial cells or the degradation of the basement membrane.
Role in Disease
Intussusceptive angiogenesis plays a significant role in various diseases, including cancer, pulmonary hypertension, and chronic obstructive pulmonary disease (COPD). In cancer, it contributes to tumor growth and metastasis. In pulmonary hypertension and COPD, it leads to the remodeling of pulmonary vessels.
Related Terms
- Angiogenesis: The physiological process through which new blood vessels form from pre-existing vessels.
- Sprouting angiogenesis: A type of angiogenesis where new blood vessels form by sprouting from existing ones.
- Endothelial cells: Cells that line the interior surface of blood vessels and lymphatic vessels.
- Basement membrane: A thin, fibrous, extracellular matrix of tissue that separates the lining of an internal or external body surface from underlying connective tissue.
- Cancer: A group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
- Pulmonary hypertension: A type of high blood pressure that affects the arteries in the lungs and the right side of the heart.
- Chronic obstructive pulmonary disease (COPD): A type of obstructive lung disease characterized by long-term breathing problems and poor airflow.
External links
- Medical encyclopedia article on Intussusceptive angiogenesis
- Wikipedia's article - Intussusceptive angiogenesis
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