MODY 3
MODY 3
MODY 3 (pronounced: /ˈmɒdi θri:/), also known as Maturity-Onset Diabetes of the Young type 3, is a form of diabetes that is often diagnosed in adolescence or early adulthood.
Etymology
The term "MODY 3" is an acronym derived from Maturity-Onset Diabetes of the Young type 3. The term "maturity-onset" refers to the early age at which the condition typically manifests, while "diabetes" is derived from the Greek word "diabainein", meaning "to pass through", referring to the excessive urination often associated with the condition. The "3" denotes that it is the third subtype of MODY identified.
Definition
MODY 3 is a monogenic form of diabetes that is caused by mutations in the HNF1A gene. This gene provides instructions for producing a protein that is involved in regulating other genes, particularly in the liver and pancreas. Mutations in the HNF1A gene disrupt the normal function of insulin, leading to the symptoms of diabetes.
Symptoms
The symptoms of MODY 3 are similar to those of other forms of diabetes and may include frequent urination, excessive thirst, fatigue, blurred vision, and unexplained weight loss. However, people with MODY 3 often have mild symptoms that may go unnoticed for many years.
Diagnosis
Diagnosis of MODY 3 typically involves genetic testing to identify mutations in the HNF1A gene. Other diagnostic tests may include blood glucose testing and urine tests to check for the presence of glucose and ketones.
Treatment
Treatment for MODY 3 typically involves managing blood glucose levels through a combination of diet, exercise, and medication. Some people with MODY 3 may also require insulin therapy.
Related Terms
External links
- Medical encyclopedia article on MODY 3
- Wikipedia's article - MODY 3
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