MODY 4

From WikiMD

Infobox Disease
Classification and external resources
ICD-10G71.2
ICD-9359.0
OMIM161800 256030 605355
DiseasesDB31991 33448 33447
eMedicineneuro/76 neuro/230
MeSHD001321, D015518, D015518
GeneReviews

MODY 4 is a form of maturity onset diabetes of the young.

MODY 4 arises from mutations of the Pdx-1 homeobox gene on chromosome 13. Pdx-1 is a transcription factor vital to the development of the embryonic pancreas. Even in adults it continues to play a role in the regulation and expression of genes for insulin, GLUT2, glucokinase, and somatostatin.

MODY 4 is so rare that only a single family has been well-studied. A child born with pancreatic agenesis (absence of the pancreas) was found to be homozygous for Pdx-1 mutations. A number of older relatives who were heterozygous had mild hyperglycemia or diabetes. None were severely insulin-deficient and all were controlled with either diet or oral hypoglycemic agents.

References

  1. REDIRECT Template:Transcription factor and coregulator deficiencies
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