Multidrug-resistant TB
Multidrug-resistant TB
Multidrug-resistant TB (MDR-TB), pronounced as /ˈmʌltiˌdrʌɡ rɪˈzɪstənt tiː biː/, is a specific form of tuberculosis that is resistant to at least two of the most potent antituberculosis drugs, isoniazid and rifampicin.
Etymology
The term "multidrug-resistant TB" is derived from the English words "multi" meaning many, "drug" referring to a medicine or other substance which has a physiological effect when ingested or otherwise introduced into the body, and "resistant" meaning able to withstand or repel. "TB" is an abbreviation for "tuberculosis", a disease caused by the bacterium Mycobacterium tuberculosis.
Definition
Multidrug-resistant TB is a form of TB that does not respond to, at least, isoniazid and rifampicin, the two most powerful, first-line (or standard) anti-TB drugs. MDR-TB usually develops when an individual does not complete the full course of treatment, when healthcare providers prescribe the wrong treatment, the wrong dose, or length of time for taking the drugs, or due to the lack of drug supply.
Related Terms
- Extensively drug-resistant TB (XDR-TB): A more severe form of MDR-TB, XDR-TB is resistant to isoniazid and rifampicin, plus any fluoroquinolone and at least one of three injectable second-line drugs.
- Primary MDR-TB: This occurs when a person becomes infected with a resistant strain of TB from another person.
- Secondary MDR-TB: This occurs when a person develops a resistant strain of TB due to inappropriate TB treatment.
See Also
External links
- Medical encyclopedia article on Multidrug-resistant TB
- Wikipedia's article - Multidrug-resistant TB
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