Neonatal cholestasis
Neonatal Cholestasis
Neonatal cholestasis (pronunciation: nee-oh-nay-tal koh-les-tay-sis) is a medical condition that occurs in newborns, where there is impaired or blocked bile flow from the liver. The term is derived from the Greek words "neonatos" (newborn) and "cholestasis" (stopping or slowing down of bile flow).
Causes
Neonatal cholestasis can be caused by a variety of factors, including genetic disorders, infections, metabolic disorders, and anatomical abnormalities. Some of the most common causes include biliary atresia, Alagille syndrome, and progressive familial intrahepatic cholestasis (PFIC).
Symptoms
The primary symptom of neonatal cholestasis is jaundice, which is characterized by a yellowing of the skin and eyes. Other symptoms may include dark urine, pale stools, and an enlarged liver.
Diagnosis
Diagnosis of neonatal cholestasis typically involves a combination of blood tests, imaging studies, and sometimes a liver biopsy. The aim is to determine the cause of the cholestasis and to assess the extent of liver damage.
Treatment
Treatment for neonatal cholestasis depends on the underlying cause. It may involve medications to improve bile flow, nutritional support, and in some cases, liver transplantation.
Prognosis
The prognosis for neonatal cholestasis varies widely and depends on the underlying cause. Early diagnosis and treatment can significantly improve the outcome.
See Also
- Cholestasis
- Biliary Atresia
- Alagille Syndrome
- Progressive Familial Intrahepatic Cholestasis
- Liver Transplantation
External links
- Medical encyclopedia article on Neonatal cholestasis
- Wikipedia's article - Neonatal cholestasis
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