Neurokinin 1 receptor

The Neurokinin 1 receptor (NK1R), also known as the Substance P receptor (SPR), is a G protein-coupled receptor that in humans is encoded by the TACR1 gene.

Pronunciation

Neurokinin 1 receptor is pronounced as /ˌnʊəroʊˈkɪnɪn wʌn rɪˈsɛptər/.

Etymology

The term "Neurokinin" is derived from "neuro" meaning nerve and "kinin" meaning a substance produced in the body that causes inflammation and pain. The "1" denotes the first of its kind to be discovered.

Function

The Neurokinin 1 receptor is a member of the tachykinin receptor sub-family of G protein-coupled receptors. It is found in high concentrations in the vomiting center of the brain, where it is believed to be involved in the induction of vomiting and the regulation of pain.

Clinical significance

The Neurokinin 1 receptor is the primary target of the drug aprepitant, which is used to prevent chemotherapy-induced nausea and vomiting. In addition, it has been implicated in a variety of diseases, including depression, anxiety, and migraine.

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Neurokinin 1 receptor

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