Paraneoplastic acrokeratosis
Paraneoplastic Acrokeratosis
Paraneoplastic acrokeratosis (pronunciation: /ˌpærəniːəʊˈplæstɪk ækroʊkɛrəˈtoʊsɪs/), also known as Bazex syndrome, is a rare paraneoplastic syndrome associated with underlying malignancies, most commonly squamous cell carcinoma of the upper aerodigestive tract.
Etymology
The term "paraneoplastic" is derived from the Greek words "para" (beside) and "neoplasia" (new growth), indicating a disorder that is the result of the presence of cancer in the body but is not due to the local presence of cancer cells. "Acrokeratosis" comes from the Greek "akron" (extremity), "keras" (horn), and "-osis" (condition), referring to the characteristic skin changes seen in this condition.
Symptoms
The primary symptom of paraneoplastic acrokeratosis is the presence of skin lesions, particularly on the extremities and face. These lesions are often psoriasiform and may be accompanied by nail changes, such as onycholysis (separation of the nail from the nail bed) and hyperkeratosis (thickening of the skin).
Diagnosis
Diagnosis of paraneoplastic acrokeratosis is primarily clinical, based on the characteristic skin findings and the presence of an underlying malignancy. Skin biopsy may be performed to confirm the diagnosis.
Treatment
Treatment of paraneoplastic acrokeratosis primarily involves addressing the underlying malignancy. Skin symptoms may improve with treatment of the cancer. Topical treatments, such as corticosteroids, may also be used to manage skin symptoms.
Related Terms
External links
- Medical encyclopedia article on Paraneoplastic acrokeratosis
- Wikipedia's article - Paraneoplastic acrokeratosis
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