Proteostasis
Proteostasis
Proteostasis (pronounced pro-tee-oh-stay-sis) is a term in the field of Biology and Biochemistry that refers to the regulation of the cellular protein pool. It is a portmanteau of the words "protein" and "homeostasis".
Etymology
The term "Proteostasis" is derived from the combination of "protein", a complex molecule that is essential for the structure and function of the body's cells, and "homeostasis", a term in biology that refers to the ability of an organism or cell to maintain internal equilibrium by adjusting its physiological processes.
Definition
Proteostasis involves the balance of protein synthesis, folding, translocation, and degradation. It is a critical process for cell function and survival. Disruptions in proteostasis can lead to the accumulation of misfolded proteins, which can cause a variety of diseases, including Alzheimer's disease, Parkinson's disease, and Cystic fibrosis.
Related Terms
- Protein synthesis: The process by which cells generate new proteins.
- Protein folding: The process by which a protein structure assumes its functional shape or conformation.
- Protein degradation: The process by which cells break down and recycle proteins.
- Protein homeostasis: The balance of protein synthesis and degradation to maintain cellular function.
See Also
- Chaperone (protein): Proteins that assist in the folding of other proteins.
- Ubiquitin: A small protein that is used to tag proteins for degradation.
- Autophagy: The process by which cells recycle their own components, including proteins.
External links
- Medical encyclopedia article on Proteostasis
- Wikipedia's article - Proteostasis
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