RTS,S
RTS,S
RTS,S (/ɑːr tiː ɛs ɛs/), also known as RTS,S/AS01, is a recombinant protein-based malaria vaccine. It is the first, and currently the only, vaccine to show partial protection against malaria in young children.
Pronunciation
The pronunciation of RTS,S is /ɑːr tiː ɛs ɛs/.
Etymology
The name RTS,S is derived from its makeup. The 'R' refers to the central repeat region of the Plasmodium falciparum circumsporozoite protein (CSP), 'T' stands for the T-cell epitopes of CSP, and 'S' represents the Hepatitis B surface antigen (HBsAg). The second 'S' stands for the HBsAg that is present in the vaccine without any attached CSP parts.
Related Terms
- Recombinant protein: A protein that is derived from recombinant DNA.
- Malaria: A life-threatening disease caused by parasites that are transmitted to people through the bites of infected female Anopheles mosquitoes.
- Plasmodium falciparum: A protozoan parasite, one of the species of Plasmodium that cause malaria in humans.
- Circumsporozoite protein (CSP): A protein on the surface of the malaria parasite that plays a key role in its ability to infect the human host and the mosquito vector.
- Hepatitis B: A viral infection that attacks the liver and can cause both acute and chronic disease.
- Hepatitis B surface antigen (HBsAg): A protein antigen produced by HBV that is used in the RTS,S vaccine.
External links
- Medical encyclopedia article on RTS,S
- Wikipedia's article - RTS,S
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