Ranibizumab
Ranibizumab
Ranibizumab (pronounced rah-ni-BIZ-uh-mab) is a monoclonal antibody fragment (Fab) derived from the same parent mouse antibody as Bevacizumab. It is much smaller than the parent molecule and has been affinity matured to provide stronger binding to Vascular Endothelial Growth Factor A (VEGF-A).
Etymology
The name "Ranibizumab" is derived from the parent molecule "Bevacizumab", with the prefix "Rani-" denoting its smaller, refined nature and the suffix "-mab" indicating its status as a monoclonal antibody.
Usage
Ranibizumab is used to treat wet age-related macular degeneration (AMD), a condition that can lead to vision loss. It works by inhibiting the growth of abnormal blood vessels in the retina, a process driven by VEGF-A. It is also used to treat macular edema following retinal vein occlusion, diabetic macular edema, and diabetic retinopathy.
Related Terms
- Monoclonal Antibody: A type of protein made in the lab that can bind to substances in the body, including cancer cells.
- Bevacizumab: A monoclonal antibody that inhibits angiogenesis (the formation of new blood vessels) by blocking the action of a vascular endothelial growth factor A (VEGF-A).
- Vascular Endothelial Growth Factor A (VEGF-A): A protein that plays a critical role in angiogenesis and vasculogenesis.
- Wet Age-Related Macular Degeneration (AMD): A chronic eye disorder that causes blurred vision or a blind spot in your visual field.
- Macular Edema: A condition that occurs when fluid and protein deposits collect on or under the macula of the eye and causes it to thicken and swell (edema).
- Diabetic Macular Edema: A complication of diabetes that occurs when fluid accumulates in the macula, or central portion of the eye, leading to vision loss.
- Diabetic Retinopathy: A diabetes complication that affects eyes and can cause blindness.
External links
- Medical encyclopedia article on Ranibizumab
- Wikipedia's article - Ranibizumab
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