From WikiMD
Jump to navigation Jump to search
Other languages:

Information about Ropinirole

Ropinirole is a selective dopamine receptor agonist used in the therapy of Parkinson disease.

Liver safety of Ropinirole

Ropinirole therapy is associated with low rate of transient serum enzyme elevations during treatment and has been implicated in rare cases of acute liver injury.

Mechanism of action of Ropinirole

Ropinirole (roe pin' i role") is a synthetic, nonergot derivative dopamine receptor agonist that has selective activity for the D2 class of dopamine receptors and little agonist activity for the D1 class.  For this reason, ropinirole may be better tolerated than bromocriptine or pergolide, which act on both classes of dopamine receptors. 

FDA approval information for Ropinirole

Ropinirole was approved for use in the United States in 1997 for the therapy of symptomatic Parkinson disease.  Indications were later expanded to include restless legs syndrome.  Ropinirole is available in tablets of 0.25, 0.50, 1, 2, 3, 4 and 5 mg under the brand name of Requip.  Ropinirole is typically initiated in low doses, with adjustment upwards based upon tolerance and clinical effects.  In treatment of Parkinson disease, the typical dose of ropinirole is 3 to 6 mg daily in three divided doses, often but not always in combination with levodopa/carbidopa.  Ropinirole can be initiated more quickly than bromocriptine or pergolide and does not cause the profound hypotension and nausea that are typical of the ergot derivatives.  Rolinirole is also approved for use in restless legs syndrome, typically starting at 0.25 mg daily, 1 to 3 hours before bedtime, and increasing the dose slowly based upon tolerance and effect. 

Side effects of Ropinirole

Common side effects of ropinirole include somnolence, fatigue, vivid dreams, anxiety, confusion, depression, dizziness, headache and gastrointestinal upset, symptoms that are typical of dopaminergic stimulation.

Antiparkinson agents

Antiparkinson agents

Dopamine Precursors

Dopamine Receptor Agonists

Selective MAO Inhibitors

COMT Inhibitors


Cost and Coupons - Ropinirole

Reviews for Ropinirole

This article is a stub. YOU can help Wikimd by expanding it!

Articles on Ropinirole


Learn more about Ropinirole

Help WikiMD

Find something you can improve? Join WikiMD as an an editor and help improve this page or others.

Apple bitten.svg

WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP*

Other languages:

Quick links: Medicine Portal | Encyclopedia‏‎‏‎ | Gray's Anatomy‏‎ | Topics‏‎ |‏‎ Diseases‏‎ | Drugs | Wellness | Obesity‏‎ | Metabolic syndrome | Weight loss*
Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer.
Link to this page: <a href="">Ropinirole</a>

  • Individual results may vary for weight loss from our sponsors.