Rowell's syndrome
Rowell's Syndrome
Rowell's Syndrome (pronounced roh-well's sin-drome) is a rare and controversial autoimmune disease characterized by the coexistence of Lupus Erythematosus, a chronic inflammatory disease that affects various parts of the body, particularly the skin, joints, kidneys, and nervous system, with Erythema Multiforme, a skin disorder resulting from an allergic reaction or infection.
Etymology
The syndrome is named after N. Rowell, who first described the condition in 1963. The term "syndrome" is derived from the Greek word "syndromē," which means "concurrence of symptoms," or "running together."
Symptoms
The primary symptoms of Rowell's Syndrome include:
- Erythema Multiforme: This is characterized by the sudden onset of red, often itchy or painful, patches on the skin that quickly develop into target-like lesions.
- Lupus Erythematosus: Symptoms can vary greatly from person to person, but common symptoms include fatigue, joint pain and swelling, skin rashes, and fever.
- Positive Rheumatoid Factor: This is an antibody that can be detected in the blood of most people with rheumatoid arthritis.
- Anti-nuclear Antibodies (ANA): These are autoantibodies that bind to contents of the cell nucleus. In Rowell's Syndrome, a speckled pattern of ANA is typically observed.
- Anti-La (SSB) or Anti-Ro (SSA) antibodies: These are specific types of ANA that are often found in people with certain autoimmune conditions, including lupus and Sjögren's syndrome.
Diagnosis
Diagnosis of Rowell's Syndrome is primarily based on the presence of the characteristic symptoms and signs. Laboratory tests, including blood tests to detect the presence of specific antibodies, can help confirm the diagnosis.
Treatment
Treatment of Rowell's Syndrome typically involves managing the symptoms and preventing complications. This may include the use of medications such as corticosteroids to reduce inflammation and suppress the immune system, and other drugs to manage specific symptoms.
Prognosis
The prognosis for individuals with Rowell's Syndrome can vary greatly depending on the severity of the symptoms and the individual's overall health. With appropriate treatment, most people with the syndrome can lead a normal life.
External links
- Medical encyclopedia article on Rowell's syndrome
- Wikipedia's article - Rowell's syndrome
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