Steroidal antiandrogen
Steroidal Antiandrogen
Steroidal antiandrogens (pronunciation: ster-oid-al an-tee-an-dro-jens) are a type of medication used primarily in the treatment of prostate cancer and other androgen-dependent conditions. They work by blocking the effects of androgens, which are male sex hormones.
Etymology
The term "steroidal antiandrogen" is derived from the words "steroid", referring to the chemical structure of these medications, and "antiandrogen", which describes their function of blocking the effects of androgens.
Usage
Steroidal antiandrogens are used in the treatment of conditions that are dependent on androgens for growth and survival, such as prostate cancer. They are often used in combination with other treatments, such as surgery or radiation therapy.
Mechanism of Action
Steroidal antiandrogens work by binding to the androgen receptor, preventing androgens from binding and exerting their effects. This can slow the growth of androgen-dependent tumors and can also reduce the symptoms of conditions such as benign prostatic hyperplasia.
Examples
Examples of steroidal antiandrogens include cyproterone acetate and spironolactone. These medications are typically taken orally, but can also be administered by injection.
Side Effects
Common side effects of steroidal antiandrogens can include fatigue, nausea, and breast tenderness. More serious side effects can include liver damage and an increased risk of blood clots.
Related Terms
- Androgen receptor
- Androgen deprivation therapy
- Non-steroidal antiandrogen
- Hormone therapy
- Prostate cancer
External links
- Medical encyclopedia article on Steroidal antiandrogen
- Wikipedia's article - Steroidal antiandrogen
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