Sulfonylurea

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Sulfonylurea

Sulfonylurea (pronunciation: sul-fo-nyl-yoo-ree-uh) is a class of antidiabetic medications that are used in the management and treatment of type 2 diabetes.

Etymology

The term "sulfonylurea" is derived from its chemical structure, which consists of a sulfonyl group (SO2) attached to a urea group.

Usage

Sulfonylureas work by stimulating the pancreas to secrete more insulin, thereby helping to control blood sugar levels. They are often used in combination with other antidiabetic medications for better glycemic control.

Types

There are two generations of sulfonylureas. The first-generation includes drugs like tolbutamide and chlorpropamide, while the second-generation includes drugs like glipizide, glyburide, and glimepiride.

Side Effects

Common side effects of sulfonylureas include hypoglycemia, weight gain, and skin rash. Severe side effects may include cardiovascular disease and hepatotoxicity.

Related Terms

External links

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