2-Methoxyethyl-18-methoxycoronaridinate

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Chemical compound



2-Methoxyethyl-18-methoxycoronaridinate is a chemical compound that belongs to the class of alkaloids. It is a derivative of coronaridine, which is a naturally occurring ibogaine alkaloid. This compound is of interest in the field of pharmacology due to its potential effects on the nervous system.

Structure and Properties

2-Methoxyethyl-18-methoxycoronaridinate is characterized by its complex molecular structure, which includes a methoxyethyl group and a methoxy group attached to the coronaridine backbone. The presence of these functional groups can influence the compound's solubility, stability, and bioavailability.

Synthesis

The synthesis of 2-Methoxyethyl-18-methoxycoronaridinate involves several steps, starting from the extraction of coronaridine from natural sources or its chemical synthesis. The methoxyethyl and methoxy groups are introduced through specific chemical reactions that require precise conditions to ensure the correct attachment to the coronaridine structure.

Pharmacological Effects

As a derivative of coronaridine, 2-Methoxyethyl-18-methoxycoronaridinate may exhibit similar pharmacological properties. Coronaridine and its derivatives are known to interact with neurotransmitter systems, potentially affecting dopamine and serotonin pathways. These interactions can lead to effects on mood, perception, and behavior.

Potential Applications

Research into 2-Methoxyethyl-18-methoxycoronaridinate is ongoing, with interest in its potential applications in treating neurological disorders and addiction. Its ability to modulate neurotransmitter systems makes it a candidate for further study in these areas.

Safety and Toxicology

The safety profile of 2-Methoxyethyl-18-methoxycoronaridinate is not fully established. As with many alkaloids, there is a potential for toxicity, and careful evaluation is necessary to determine safe dosage levels and possible side effects.

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Contributors: Prab R. Tumpati, MD