5-HT1E receptor
5-HT1E receptor is a serotonin receptor that is encoded by the HTR1E gene in humans. It is a subtype of the 5-HT1 receptor that binds to the neurotransmitter serotonin, also known as 5-hydroxytryptamine (5-HT).
Function[edit]
The 5-HT1E receptor is expressed in various regions of the human brain but its specific role is not well understood due to the lack of selective pharmacological tools, specific antibodies, and preclinical models. However, it is known to play a role in the modulation of mood and cognition.
Structure[edit]
The 5-HT1E receptor is a G protein-coupled receptor (GPCR) that is coupled to the Gi protein. It is composed of seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus. The receptor is activated by serotonin binding to its extracellular domain, which triggers a conformational change and activates the intracellular G protein.
Pharmacology[edit]
The 5-HT1E receptor has a high affinity for serotonin and is activated by various serotonin agonists. However, there are currently no selective agonists or antagonists for the 5-HT1E receptor, which has limited the study of its function and pharmacology.
Clinical significance[edit]
Alterations in the function or expression of the 5-HT1E receptor have been implicated in various neurological and psychiatric disorders, including migraine, depression, and schizophrenia. However, the specific role of the 5-HT1E receptor in these conditions is not well understood and is the subject of ongoing research.
See also[edit]
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