5-HT6 receptor

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5-HT6 receptor

The 5-HT6 receptor (pronounced as "five H T six receptor") is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gs and mediates excitatory neurotransmission.

Etymology

The term "5-HT6 receptor" is derived from the chemical name for serotonin, 5-hydroxytryptamine, and the fact that it is the sixth subtype of serotonin receptor to be discovered.

Function

The 5-HT6 receptor is thought to play a significant role in the regulation of mood, anxiety, and the sleep-wake cycle. It is also involved in the regulation of feeding behavior and energy balance. Antagonists of the 5-HT6 receptor are being investigated for the treatment of obesity and cognitive disorders.

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