8-azaguanine
8-Azaguanine (pronounced as eight-aza-gua-nine) is a type of guanine analog that is often used in scientific research, particularly in the field of genetics and molecular biology.
Etymology
The term "8-Azaguanine" is derived from its chemical structure, which is a guanine molecule where the 8th carbon atom is replaced by a nitrogen atom (aza- is a prefix in chemistry indicating the presence of nitrogen).
Definition
8-Azaguanine is a purine analog that is used as an antimetabolite in the treatment of certain types of cancer. It works by interfering with the synthesis of nucleic acids, thus inhibiting the growth of rapidly dividing cells such as cancer cells.
Related Terms
- Guanine: One of the four main nucleobases found in the nucleic acids DNA and RNA.
- Purine: A heterocyclic aromatic organic compound that consists of a pyrimidine ring fused to an imidazole ring.
- Antimetabolite: A type of drug that interferes with the normal metabolism of cells, often used in cancer treatment.
- Nucleic Acid: A complex organic substance present in living cells, especially DNA or RNA, whose molecules consist of many nucleotides linked in a long chain.
Usage in Research
In research, 8-Azaguanine is often used as a selective agent in mutation detection and creation of genetically modified organisms. It is also used in the study of DNA repair mechanisms.
See Also
External links
- Medical encyclopedia article on 8-azaguanine
- Wikipedia's article - 8-azaguanine
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