90Y-DOTA-biotin
90Y-DOTA-biotin
90Y-DOTA-biotin (pronunciation: 90-Y-D-O-T-A-bio-tin) is a radioactive compound used in nuclear medicine for the treatment of certain types of cancer.
Etymology
The term "90Y-DOTA-biotin" is derived from the components that make up the compound. "90Y" refers to Yttrium-90, a radioactive isotope of Yttrium. "DOTA" is an acronym for 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, a chelating agent used to bind the Yttrium-90. "Biotin" is a type of vitamin B that is used to target cancer cells.
Usage
90Y-DOTA-biotin is used in a procedure known as pretargeted radioimmunotherapy. In this procedure, a biotinylated antibody is first administered to the patient. This antibody binds to the cancer cells. The 90Y-DOTA-biotin is then administered. The biotin component of the compound binds to the biotinylated antibody, delivering the radioactive Yttrium-90 to the cancer cells.
Related Terms
- Yttrium-90
- DOTA
- Biotin
- Pretargeted radioimmunotherapy
- Antibody
- Chelating agent
- Nuclear medicine
- Cancer
External links
- Medical encyclopedia article on 90Y-DOTA-biotin
- Wikipedia's article - 90Y-DOTA-biotin
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