Abitesartan
A detailed overview of the pharmaceutical drug Abitesartan
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Abitesartan is a pharmaceutical drug that belongs to the class of angiotensin II receptor antagonists, commonly known as ARBs. It is primarily used in the management of hypertension and certain types of heart failure.
Mechanism of Action
Abitesartan works by selectively blocking the binding of angiotensin II to the angiotensin II receptor type 1 (AT1 receptor) in various tissues, including the vascular smooth muscle, adrenal gland, and kidney. This inhibition prevents the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to a decrease in blood pressure.
Pharmacokinetics
Abitesartan is administered orally and is well absorbed from the gastrointestinal tract. It undergoes minimal first-pass metabolism and is primarily excreted unchanged in the urine and feces. The drug has a half-life of approximately 12 hours, allowing for once-daily dosing.
Clinical Uses
Hypertension
Abitesartan is indicated for the treatment of hypertension to lower blood pressure and reduce the risk of cardiovascular events such as stroke and myocardial infarction.
Heart Failure
In patients with heart failure, Abitesartan is used to improve symptoms and reduce the risk of hospitalization and mortality.
Side Effects
Common side effects of Abitesartan include dizziness, headache, and fatigue. Rare but serious side effects may include angioedema and renal impairment.
Contraindications
Abitesartan is contraindicated in patients with known hypersensitivity to the drug or any of its components. It should not be used during pregnancy due to the risk of fetal harm.
Related pages
Abitesartan
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