Acivicin
Acivicin (pronounced as a-si-vi-sin) is a glutamine antagonist that is derived from the fermentation of Streptomyces sviceus. It is a naturally occurring antibiotic and has been studied for its potential use in the treatment of various types of cancer.
Etymology
The term "Acivicin" is derived from the name of the bacterium Streptomyces sviceus from which it is produced. The "-cin" suffix is common in antibiotics, indicating its bacterial origin.
Pharmacology
Acivicin works by inhibiting the enzyme glutamine amidotransferase, which is necessary for the synthesis of purines and pyrimidines. By inhibiting this enzyme, Acivicin prevents the growth of cancer cells.
Clinical Use
Acivicin has been studied in clinical trials for the treatment of various types of cancer, including leukemia, lymphoma, and solid tumors. However, its use has been limited due to its significant toxicity.
Related Terms
- Glutamine
- Streptomyces sviceus
- Antibiotic
- Cancer
- Glutamine amidotransferase
- Purines
- Pyrimidines
- Leukemia
- Lymphoma
External links
- Medical encyclopedia article on Acivicin
- Wikipedia's article - Acivicin
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